Stress, Telomeres, and Aging

by Nina

In his next post, Brad will be writing about one of the several competing theories about aging: Nobel Prize winner Dr. Elizabeth Blackburn’s theory of the relationship between aging and telomeres (the protective caps at the ends of our chromosomes). Dr. Blackburn believes that telomere length is an indicator of the age and vitality of a cell, and that psychological stress actually ages cells, which can be seen when telomere length is measured.

We thought you might be interested in Dr. Blackburn’s work because she is so convinced about the effects of stress on cellular aging that she is studying the effects of meditation and yoga on telomeres. So for those of you who would like to learn a bit about her work before Brad’s post, here is a little background information. As a start, you can find a brief interview with Dr. Blackburn here. If you’ve got an hour or so, you can listen to her lecture on “Chromosome Ends and Diseases of Aging” here.

Gaudi Mosaic by Brad Gibson

Throughout your life, your cells may reproduce many times to repair and strengthen their host organs, to grow or to fight disease, and the telomere at the end shrinks each time the cell divides and duplicates itself. A chemical called telomerase helps restore a portion of the telomere with each division, but after 10 to 50 divisions or so (the number varies by tissue type and health, and biologists still do not understand the system well), the telomere gets so short that the cell is no longer able to replicate. Because some cells or tissues in our body (skin, blood cells, etc.) continue to replicate and be replaced as we age, or to be repaired after injury, if the progenitor cells needed for these processes cannot replicate due to telomere shortening, this can contribute to the aging process and increase our susceptibility to disease. See here for a short article on this.

For several years, Dr. Blackburn has been conducting research on the relationship between stress and telomere length. According to her, there is so much evidence that psychological stress actually ages cells that she and her colleagues have been studying the effects of mindful meditation on telomere length. See here for a full academic paper entitled “Can meditation slow the rate of cellular aging?” I've read that as a result of these studies, Dr. Blackburn has taken up meditation as regular practice.

To be continued....

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